نشریه دانشگاه علوم پزشکی خراسان شمالی
سال دوازدهم شماره 2 (تابستان 1399)

Serum Amyloid A (SAA) is a sensitive marker related to the acute inflammatory phase, produced in the liver, and has got the protection and repair role in the inflammatory process. Nano curcumin (turmeric pigment) is anti-inflammatory and antioxidant. The purpose of this study was to evaluate the impact of advanced aerobic training and Nano curcumin supplementation on body composition and SAA levels in overweight and obese women.

In this quasi-experimental study،The Forty-Four women with (age 28.7 ± 3.33 years, BMI 31.53 ± 4.86 kg/m2 and WHR 0.82 ± 0.07 cm) above 25 kg/m2 were selected purposefully and were randomly divided into four groups of advanced aerobic training (n = 12), advanced aerobic training+ Nano curcumin (n = 12), Nano curcumin (n = 10) and control (n = 10) and for 8 weeks, they performed advanced aerobic exercise and daily intake of a Nano curcumin 80 m/g nanomicelle capsule. The Nano curcumin and control groups had no physical activity during the period. Fasting blood samples were taken 24 hours before and 48 hours after the last training session and serum levels were measured by ELISA using human kits. For data normality, K-S test and dependent t-test and analysis of ANOVA were used to test the hypothesis.

The results showed that eight weeks of training ،supplementation ،and train +supplementation group significantly decreased SAA about pre-exercise values (P =0.001) There was also a significant difference between the four groups (P < 0.05).

Improved aerobic exercise and Nano curcumin appear to be effectivein reducing the inflammatory status of overweight and obese women as well as inreducing body weight by reducing inflammatory factors.

The anti-inflammatory drugs are associated with some side effects. The herbal medicine has fewer side effects. In the present study, the anti-inflammatory effects of the alcoholic extract of Cyperus rotundus were investigated on acute inflammation in male mice.

In this experimental study, 30 mice were randomly assigned into 5 groups of 6, including the solvent group (physiological serum), the control group (carrageenan only), 2 groups of 100 and 300 mg/kg extract, and the last group received ibuprofen. Inflammation in mice with subcutaneous injection of 0.25 ml of 0.5% solution of carrageenan was created into the animalchr('39')s foot.

The results of this study showed that the mean of changes in inflammation was significant among the groups (P < 0.001). The process of inflammatory changes in all tested groups was initially increased and its maximum value was 2 hours after injection. Then, the process of reduction of inflammation started at the same time reducing the inflammation in the treatment groups with extract significantly compared to the negative and positive control groups It happened faster (P ≤ 0.01).

The present study showed that Cyperus rotundus extract has significant anti-inflammatory effects; however, additional researches are needed to understand the possible mechanism of this effect.

Obesity is increasing epidemically at the age of 3-6 years, and one of the most critical risk factors of childhood overweight is the reduction of breastfeeding. Childhood obesity is also a strong predictor of obesity in adulthood. This study aimed to determine the relationship between exclusive breastfeeding and body mass index in children 3-6 years old.

In this retrospective observational study, which was carried out on the population of children 3 to 6 years old in Bojnourd in 2019, 445 children were selected through multi-stage sampling from kindergartens and kindergartens in Bojnourd. The required information was then obtained through the demographic profile checklist and the baby mass index. Data were analyzed by SPSS 19 software using statistical tests.

There was no statistically significant difference between the two groups despite the prolonged duration of exclusive breastfeeding in the overweight group.

Among the variables studied, higher body mass index in the mother has a direct relationship with the weight gain of children. Weight loss in neonates with obesity shows the opposite. This means that the average birth weight in the low birth weight group was less than the average birth weight in desirable and overweight children.

Today, following the aging population, the elderly have been faced with various social issues. The social well-being and health of the elderly are important but it has been neglected that is closely related to the quality of life. The Social Comfort Scale has not been validated in the Iranian elderly. The purpose of this study was to investigate the Psychometrics properties of Social Well-being Scale in Iranian Elderly.

This is a psychometrics properties study. The participants were 550 elderly people living in Tehran who were randomly selected from health centers. The study was conducted on the Social Well-being Scale. The data were analyzed using descriptive statistics and Pearson correlation test, exploratory factor analysis, and Cronbachchr('39')s alpha via SPSS v.22 software.

Participants were 58.9% male and 41.1% female. The mean age was 66.09 ± 6.67. Alpha Cronbachchr('39')s was 0.94. Structural validity by exploratory factor analysis showed that SWS consisted of five components (social integration, social acceptance, social contribution, social actualization, and social coherence).

Social Well-being Scale has good reliability and validity in Iranian elderly. Therefore, it can be used to assess the social well-being and health of Iranian elderly.

Fleas are the external parasites of birds and mammals which in addition to causing harassment and skin sensitivities in the host, are also vectors of important diseases such as plague. This study was aimed to study and identify medically important species of fleas in Bojnourd city of North Khorasan province.

This study is a descriptive cross-sectional study. Sampling was carried out for 7 months from April to October 2018 in rural areas of Bojnourd city of North Khorasan province. Using the cluster sampling method, eleven villages were randomly selected according to geographical location (north, south, east, west and center). Samples were captured using different sampling methods from animal and human sites, and after preparation and mounting, were identified using a valid identification key.

In the present study, a total of 1540 flea were collected using different sampling methods. Captured fleas were from the Placida family included four species of Pulex irritans (94.2%), Ct. felis. felis, (2.1%), Ct. canis (1.2%) and Xenopsylla cheopis (2.5%). 41 % (631) of the samples were male and 59% (909) were female. The dominant species was Pulex irritans and the highest abundance of fleas was observed in Timurtash village (77.7%).

The results of this study showed that Pulex irritans is the dominant species and has the highest abundance in Bojnourd city which can be considered as a health problem. Therefore, planning to control it is very important.

Midwives are always faced with ethical challenges in their day care, so they need to be aware of the legal and professional aspects of their care. The purpose of this study was to evaluate knowledge of midwives about rules and regulations and professional Ethical codes in North Khorasan hospital in 2018.

This descriptive cross-sectional study was performed on midwives working in the maternity department of affiliated hospitals of North Khorasan province in 2018 using census method. The tools used in this study were demographic questionnaire and knowledge of professional ethics codes and midwifery rules and regulations. Data were analyzed by SPSS software (version 16) and descriptive statistics, Mann-Whitney U, Kruskal-Wallis, Spearman correlation coefficient. P value less than 0.05 was considered significant.

In this study, the mean of midwives chr('39')knowledge of professional ethics codes was 7.82 ± 1.88 and the mean of midwiveschr('39') knowledge of midwifery rules and regulations was12.7 ± 2.89. Most people had moderate awareness of professional ethical codes in 66 (78.6%) and 40 (47.6%) of them had low and 40 (47.6%) of them had moderate knowledge of midwifery laws and regulations.

Due to insufficient midwiveschr('39') awareness of professional ethical codes and midwifery rules and regulations, implementation of retraining programs to improve midwivechr('39')s awareness in order to improve performance and increase satisfaction as well as reduce health errors seems necessary.

Beetroot is a nutritious food in the food industry, but its importance is not well known among athletes. This natural supplement can effectively enhance and control immunity factors, lipid peroxidation, cellular protein carbonylation, and counteracting oxidative indices. Therefore, the aim of this study was to investigate the effects of resistance training and beet juice supplementation on CRP, LOOH, and PC in male rats.

In this experimental study, 48 Vistar male rats (8-10 weeks of age) were first familiarized with the new environment, and then assigned randomly to four groups (n = 12, 210 ± 20 g): resistance training, resistance training + supplement, supplement, and placebo. The exercise protocol was designed with an intensity of 70-75% of rat weights and continued increasingly for 8 weeks, with four sessions aweek. Beetroot juice in supplement and supplement + resistance training groups wasprovided as gavage with a dose 8 mg/kg/bw. Blood samples were collectedimmediately after the last training session with similar conditions. One-way analysisof variance and Bonferroni test were used to determine the significance of thechanges (P ≤ 0.05).

After 8 weeks, significant reductions were observed in values of CRP (P =0/05), LOOH (P = 0/001) and PC (P = 0/004) in the resistance training + supplementand supplement groups.

The results of this research showed that adaptation to the protocol oftraining and beet juice supplementation could exert its antioxidant effects byreducing CRP, lipid peroxidation, and protein carbonylation hence this supplementcan be used to improve the immune system.

Improvement and success of the organization includes a wide range of activities with endless developments, and in order to increase organizational success, it is necessary to identify content and structural factors as well as social capital in the administrative system. Therefore, the present study aims to design the role model of the content and structural factors on the organization with social capital and organizational success in Arak University of Medical Sciences.

This research is developmental in terms of purpose and descriptive-analytical in nature. The statistical population of the study was all employees of Arak University of Medical Sciences, from which a sample of 305 people was selected. A researcher-made questionnaire was used to collect information. Descriptive and inferential statistical methods (correlation test and structural equation modeling) were used to analyze the data.

Based on the opinions and suggestions of experts, five dimensions (strategy and goals, technology, size, organizational culture and environment) are content factors and three dimensions (complexity, formality and Focus) are Structural factors in model. Organizational success with three-dimensional (organizational agility, knowledge sharing and innovation) and social capital with three-dimensional (structural, specialized, and communicative) are in the model. Structural factors have a significant positive effect on organizational success(r = 0.120) and social capital(r = 0.116), and content factors have a significant effect on organizational success(r = 0.780) and social capital(r = 0.771).

According to the final model and the positive effect of structural and content factors on organizational success and social capital, by controlling these factors, organizational success and social capital can be strengthened.

IgA Nephropathy is the most common form of glomerulonephritis and the major cause of end-stage renal disease. Gross or microscopic hematuria is a common symptom of hematuria and occurs in less than 5% to 10% of patients with IGM with rapidly progressive glomerulonephritis. The aim of this study was to investigate the diagnostic biomarkers of this disease after biopsy.

IgA (N) Nephropathy is the most common glomerulonephritis in the world and is currently recognized as an important end-stage renal disease (ESRD). Hypertension, proteinuria greater than 1 g / day, and severe lesions in primary renal biopsies such as crescent and interstitial fibrosis are the major predictors of progression to ESRD. Despite its prevalence and clinical significance, there is no consensus for treating patients with risk factors for worse prognosis. Our aim is to describe cases of crescentic IgA N and emphasize the efficacy of immunosuppressive therapy here.

This is a case-control study of the physiological and pathologic features of a patient with clinical, radiologic, and treatment modalities of a patient with immunoglobulin A nephropathy without a history of renal disease.

IgA Nephropathy, first identified nearly four decades ago as one of the types of kidney disease, is one of the most common causes of primary glomerulonephritis in developing countries and is now one of the major causes (End - stage renal disease (ESRD).

The purpose of this study was to compare the Dissociative Experiences and a six-dimensional conceptualization of emotion dysregulation between people who have suicide ideation and suicide attempt.

Participants were patients referred to Imam Hasan Hospital of North Khorasan with suicide Attempts, and to Psychiatric clinics in north Khorasan who had suicide ideation. In a comparative casual study, a total of 141 patients of young adults were considered. 76 of them who had suicidal ideation but no suicide attempts were compared with the rest (n = 65) who had at least one suicide attempt in the last week. They completed measures of Dissociative Experiences, emotion dysregulation and suicidal ideation.

suicide Attempters reported significantly more Dissociative Experiences) P < 0.021( and difficulties with Impulse Control (P < 0.001) -which is one of the six-dimensional conceptualization of emotion dysregulation- than suicide ideators.

Screening and identification of people who have significant dissociative experiences and difficulties with impulse control is essential due to a high risk of suicide attempt. Therefore, they should be given higher priority to receive medical treatments and Psychotherapy.

One of the significant threatening health and life older adult is social isolation. Therefor need for an appropriate scale is necessary. This study was performed for validity and reliability Persian version of the Lubben social network-6 scale in elderly adults in Bojnurd.

This methodological study was a cross-sectional study conducted in 2016. Two hundred older people over sixty years old were randomly proportional to the population selected form all health care centers in Bojnurd. Interviewers completed the Persian version of lubben social network -6 scale. After calculating CVI and CVR, Cronbach alpha was used by SPSS and AMOS software and exploratory factor analysis of the first and second stages.

In the present study, 39% of the older people scored less than 12. The value CVI=0.97 and CVR= 0.91. Cronbachchr('39')s alpha for the total scale was 0.896. Exploratory factor analysis indicates two dimensions; family and friends. According to structural fit analysis X2/df = 0.988, NFI = 0.971, CFI = 0.980 and RMSA = 0.88.

The Persian version of the Lubben social network -6 scale has good validity and reliability in Iranian older people. Furthermore, given a low number of questions, it is a good tool for measuring social isolation in Persian elders.

Acetaminophen and ibuprofen are the most widely used drugs in pediatric medicine to control fever and pain. There are different opinions about the effectiveness, duration of effects, and side effects and duration of action in controlling pain and fever of these drugs. In this study, we decided to examine the antipyretic effects of two common drugs to provide solutions based on the results.

During six months in the second half of the year, 400 children referred to a pediatric clinic with fever were divided into two groups. One group was prescribed acetaminophen at a dose of 15 mg per kg every 4 to 6 hours to control fever, and the other group was prescribed ibuprofen at a dose of 10 mg per kg every 6 to 8 hours. Patients underwent telephone or in-person follow-up 24 hours after drug administration, and each group was evaluated for the time to stop fever after medication, the duration without the fever after each dose, and the interval between doses.

Four hundred children were examined and split into 185 children in the first group (acetaminophen) and 145 children in the second group (ibuprofen). In the first group, the average duration of stop the fever after taking the drug was 35 minutes, and in the second group, 55 minutes. Duration without fever after taking the drug was 2 hours in the first group and 4 hours in the second group. In the first group, drug dissatisfaction was much lower than in the second group.

The best antipyretic drug in children, especially in infections, is acetaminophen, which, of course, must be taken in sufficient and correct doses and avoid taking antipyretic drugs, which is also anti-inflammatory. Although ibuprofen and diclofenac are also antipyretics, they should not be used as antipyretics, especially in pediatric infections. Compared to acetaminophen, these drugs have both more side effects and a longer reduction in body temperature.

Due to the importance of pain control in the postoperative period, prescribing painkillers reduces postoperative complications by improving patientschr('39') pain. This study evaluated the effect of different doses of Melatonin on postoperative pain in cesarean section patients under spinal anesthesia.

In this clinical trial, 150 pregnant women enrolled the study who were candidates for elective cesarean section referring to Imam Ali (AS) Hospital in Zahedan in 1398. Patients were randomly assigned to 3 groups of melatonin 1.5 and 3 mg two hours before spinal and control groups. The severity of the pain and the need for analgesics were assessed in groups. In the end, data analyzed using SPSS software ver. Twenty-three by ANOVA and chi-square statistical tests.

The mean age of the patients was 26.3 ± 4.7 years. The results showed that with increasing melatonin dose, patientschr('39') pain decreased during recovery, 6 and 12 hours after that (P < 0.05). The first painkiller administration time was significantly higher in patients receiving Melatonin than the control group (P < 0.05). There was no significant difference in postoperative adverse effect frequencies between groups (P < 0.05).

Melatonin in different doses can be used for pain control and increasing the painlessness duration in the cesarean section.

Hypertension is one of the most common chronic diseases in the world today. Various studies have shown that people with hypertension have a lower life quality than people with normal blood pressure. Despite various studies on hypertension, little information is available on the life quality in patients with hypertension. Due to the relative ambiguity in this regard, the study has examined the quality of life in patients with hypertension.

The statistical population of the study consisted of those referring to Health Services Comprehensive Centers of Khaf city in 2019. Three hundred eighty-four persons were selected as a statistical sample based on the Morgan table. The required information was collected through a standard short questionnaire of life quality (SF-36). Data were analyzed through the techniques, including data normality test, independent t-test, and analysis of variance using SPSS 24 software.

The findings showed that the life quality means of patients with hypertension in the comprehensive health services centers of Khaf city was 52.09 ± 13.91. There was no significant difference between life qualities in different age groups. The average life quality for male and female patients is equal. Patients who have health insurance have a better life quality, and The average life quality of patients is equal in terms of marital status.

Hypertension is closely linked to patientschr('39') life quality. Therefore, considering different aspects of life quality in hypertensive patients can be a significant step in promoting community health.

Activities of daily living allows older adults to maintain their independence. Moreover, demographic variables can affect their ability to perform these activities. The present study was conducted to assess the status of activities of daily living of older adults and associated factors in the city of Bojnurd (urban and rural).

In the present cross-sectional study, a total of 450 older adults were selected by cluster sampling method. Data were collected using a demographic questionnaire, basic and instrumental life activities questionnaires. Open questions were used to assess advanced activities of daily living. Data were analyzed by SPSS-24 using non-parametric tests.

In assessing necessary activities of daily living, 95.4% of older adults were independent, 3.9% somewhat dependent, and 0.7% dependent, with a mean (standard deviation) of 15.49(1.74), which showed significant relationships with age, chronic diseases, and constant use of medications (P < 0.05). About instrumental activities of daily living, 71.5% of older adults were independent, 16.4% dependent, and 12.1% total dependent, with a mean (standard deviation) of 11.3(3.36), which showed significant relationships in terms of age, gender, education, marital status, chronic diseases, and constant use of medications (P < 0.05). Of participating older adults, 77.9% took part in social activities. These activities had significant relationships with age, gender, education, marital status, income, chronic diseases, and constant medications (P < 0.05).

Demographic factors affect the level of activities of daily living in older adults. Proper planning may improve older adultschr('39') activities and their lifestyle.